In the distant future, the war between the human race and the aliens known as the Gamilons has destroyed the Earth. Radioactive asteroids have devastated the planet making its atmosphere uninhabitable. In an effort to assist the Earth, Queen Starsha of the planet Iscandar offers the Earth Forces a device that can completely neutralize the radiation.
In order to get this device, the space battleship Yamato is launched from the remains of its World War II ancestor on a 148,000 light-year journey. The crew of the Space Battleship Yamato has only one Earth year to travel to Iscandar and back, or the human race will become extinct.