In the Chicago offices of Promethium Pharmaceuticals, co-presidents Richard Rusk and Elaine Markinson receive a call from a company employee, Harold Soyinka, who claims he has been kidnapped in Mexico and that his abductors are demanding a ransom of five million US dollars.
One day earlier, Harold, Richard, and Elaine arrive in Mexico where they meet Sanchez, head of Promethium’s Mexico plant. Unbeknownst to Harold, it is revealed that Sanchez has been selling Promethium’s latest product, medical marijuana in the shape of a pill, to a Mexican cartel. Promethium has decided to cut them off to avoid harming their upcoming merger. Later that evening, as Richard, Elaine and Harold have dinner, Harold secretly records Richard’s and Elaine’s conversations while he is away from the table. He learns from the recording the merger plans, which would result in Harold losing his job. That night, he also discovers that his wife is having an affair and wants a divorce. Sanchez informs cartel leader Villegas about them getting cut off by Promethium; Villegas maims Sanchez and, believing that Harold is Promethium’s boss, orders his capture.
Richard and Elaine leave Mexico the next morning without Harold when he seemingly disappears. Harold, hiding away at a motel, convinces the motel’s operators, brothers Ronaldo and Ernesto to pose as kidnappers in an extortion plan in which he calls Richard pretending to be kidnapped in exchange for a hefty ransom. Richard calls his former-mercenary-turned-humanitarian brother Mitch to rescue Harold.
Harold spends the evening at a bar, believing his scheme to have failed. The bartender alerts the cartel when he recognizes Harold. Two men arrive and kidnap Harold, but, while delivering him to Villegas, Harold overpowers them and crashes the car.
The next morning, Harold is rescued by tourists Sunny and Miles, the latter of whom is working as a drug mule. The two take Harold back to Ronaldo and Ernesto’s motel where all three had been staying, where Sunny befriends him. Soon, Ronaldo and Ernesto, who have been bribed by the cartel into helping them, attempt to kidnap Harold. However, Mitch arrives, defeats the brothers, and takes Harold with him. Mitch takes Harold to the airport to return him to Chicago, but he runs away. Mitch subdues Harold and injects him with a tracker to know where he is at all times. The men get on good terms with one another and devise a scheme to extort Richard for more money. When Mitch calls Richard to make that deal, Richard tells him that the company is planning to collect a large life insurance claim on Harold if he were to die, part of which Mitch would receive. Mitch reluctantly agrees to kill Harold.
Harold and Mitch are spotted by Ronaldo and Ernesto on the streets. Mitch prepares to shoot Harold but cannot bring himself to do so as he has grown fond of him. The two are then attacked by the brothers, who kidnap Harold and take him to Villegas. Villegas kills the brothers and orders Harold to access a vault at the Promethium plant in order to steal the marijuana pill formula. There, a shootout occurs when the police arrive.
During the battle, “Angel,” Harold’s Mexican colleague and one of Villegas’ men, whisks Harold away from the fight and reveals himself as an undercover DEA agent. They are chased by members of the cartel, who run them off the road. Harold saves “Angel” from being killed by a cartel member; as Harold is about to be executed by another cartel member, Mitch arrives and saves him only to be killed by the first cartel member, who Harold finishes off. Harold asks “Angel” for help, believing that he has nothing to return to in Chicago. “Angel” agrees to falsely declare Harold dead and Harold gives him company files incriminating Richard before leaving.
Villegas, his men, and Miles the drug mule are arrested by Mexican police, aided by “Angel.” Richard is arrested by the DEA and imprisoned, and Elaine, who testified against Richard, takes over Promethium. Sanchez, despite his disability, settles down happily with his children. Harold, living quietly as “Harry Barnes,” stays in Mexico, opens a beachside bar, and remains in contact with Sunny.