Following the defeat of Deckard Shaw and Mose Jakande, Dominic “Dom” Toretto and Letty Ortiz are on their honeymoon in Havana when Dom’s cousin Fernando gets in trouble owing money to local racer Raldo. Sensing Raldo is a loan shark, Dom challenges Raldo to a race, pitting Fernando’s reworked car against Raldo’s, and wagering his own Third Generation Chevrolet Impala. After narrowly winning the race, Dom allows Raldo to keep his car, earning his respect, and instead leaves his cousin with his car.
The next day, Dom is approached by the elusive cyberterrorist Cipher who coerces him into working for her by showing him an unseen photo. Shortly afterwards, Dom and his team, comprising Letty, Roman Pearce, Tej Parker, and Ramsey, are recruited by Diplomatic Security Service (DSS) agent Luke Hobbs to help him retrieve an EMP device from a military outpost in Berlin. During the getaway, Dom goes rogue, forcing Hobbs off the road and stealing the device for Cipher. Hobbs is arrested and locked up in the same high-security prison in which he helped imprison Shaw. After Shaw and Hobbs both escape the prison, they are recruited by intelligence operative Mr. Nobody and his protégé to help the team find Dom and capture Cipher. Shaw reveals that Cipher had hired his brother Owen to steal the Nightshade device and Mose Jakande to steal God’s Eye, Ramsey’s software program. The team tracks Dom and Cipher to their very location just as the latter two attack the base, causing injuries to the team, and stealing God’s Eye. Roman suggests bringing Brian in to help them, but Letty rejects the idea as they agreed not to bring him and Mia into any more missions for the sake of their children.
When Dom questions Cipher’s motives, she reveals that she has been holding hostage Dom’s ex-lover and DSS agent Elena Neves—as well as their son, of whose existence Dom was previously unaware. Elena tells Dom that she wanted him to decide the child’s first name, having already given him the middle name Marcos.
In New York City, Cipher sends Dom to retrieve a nuclear football held by the Russian Minister of Defense. Prior to the theft, Dom briefly evades Cipher—with the help of Raldo—and persuades Shaw’s mother, Magdalene Shaw, to help him. Cipher hacks into the electronics systems of a large number of cars, causing them to disable the convoy so that Dom can take the football. The team intercepts Dom, but Dom escapes, shooting and apparently killing Shaw in the process. Letty catches up to Dom, but is ambushed and nearly killed by Cipher’s enforcer, Connor Rhodes, before Dom rescues her. In retaliation, Cipher has Rhodes execute Elena in front of a helpless Dom.
Dom infiltrates a base in Russia to use the EMP device to disable their security and then to disable a nuclear submarine, enabling Cipher to hijack it and attempt to use its arsenal to trigger a nuclear war. They are once again intercepted by the team, who attempt to shut down the sub, and then drive out toward the gates that would prevent the sub from leaving into open waters. Meanwhile, Shaw, whose death was faked, teams up with Owen, and at Magdalene’s behest, infiltrates Cipher’s plane to rescue Dom’s son. Once Shaw reports that the child is safe, Dom turns on Cipher and kills Rhodes, before rejoining his team. Infuriated, Cipher fires an infrared homing missile at Dom, but he breaks away from his team and maneuvers around it, causing the missile to hit the submarine instead. The team quickly forms a vehicular blockade around Dom, shielding him from the ensuing explosion. Shaw reaches the front of the plane and confronts Cipher, who jumps from the plane with a parachute.
Mr. Nobody and his protégé visit Dom and his team in New York City to report that Cipher is still at large in Athens. Hobbs is offered his DSS job back, but he declines in order to spend more time with his daughter. Shaw delivers Dom his son, putting his differences aside with Dom and Hobbs. Dom names his son Brian, after his friend and brother-in-law Brian O’Conner, and celebrates with his friends.