Jonathan Harker, a lawyer traveling from London to Transylvania to secure property for Count Dracula, arrives at Bistritz to stay for the night. There, he is warned by a concerned lady against continuing his journey the following day. Harker believes that her concerns are rooted in peasant superstition. He ignores her, but starts to feel increasingly unnerved by the way everyone looks at him. Harker sets off for the rest of his journey and arrives at the Borgo Pass where he’s picked up by the Count’s mysterious coachman.
Harker disembarks at Castle Dracula, and the coach immediately rushes off. Somewhat hesitantly, Harker approaches the main door, whereupon a thin, tall, gaunt old man opens it. Harker asks, “Count Dracula?” “I am Dracula, enter freely and of your own will,” says the man at the door. Dracula takes Harker to his bedchamber where Harker notices that Dracula casts no reflection.
Later, Harker goes to sleep. He wakes in an ancient crypt where he is harassed by three beautiful vampiresses. Dracula rushes into the room in a rage and orders them to leave Harker alone. Dracula explains, “This man belongs to me,” then gives the vampiresses a baby to feed on. Harker wakes up screaming in his room and assumes it was a nightmare, but two small wounds on his neck indicate otherwise.
Harker soon realises he is a prisoner, and tries to escape by climbing out of his bedroom window. He finds his way back to the crypt where Count Dracula and his three brides rest in coffins. Harker runs out of the crypt screaming, and jumps out of the castle’s tower into the river below.
Harker wakes up in a private psychiatric clinic outside London, owned by Dr. Van Helsing, in the care of Dr. Seward. He is told he was found delirious in a river near Budapest. Naturally, no one believes his story about Castle Dracula until Van Helsing finds the two punctures on Harker’s neck. Harker’s fiancée Mina and her close friend Lucy also arrive at the hospital to help take care of him. Unbeknownst to them, Count Dracula has followed Harker back to England and now resides in an abandoned abbey close to the hospital.
As Mina nurses Harker back to health, her friend Lucy’s health strangely declines. Dracula has been secretly appearing to her by night and drinking her blood, growing younger as he feeds off his victim. Quincey Morris, Lucy’s fiancé, joins Drs. Seward and Van Helsing in an attempt to save Lucy by giving her a blood transfusion from Quincey.
One of the patients at the clinic, R. M. Renfield, becomes of considerable interest to the men. Renfield is classed as a zoophagus: he eats flies and insects in order to consume their life, believing that each life he consumes increases his own. He reacts violently whenever Dracula is nearby.
Lucy eventually dies while her men helplessly look on. As Van Helsing suspected, Lucy has become one of the undead and murders a young child, but the ordeal is put to an end when Quincey, Seward and Van Helsing ambush Lucy in her tomb, stake her through the heart and decapitate her. Harker, restored to health, joins the group who now are sure that Count Dracula is a vampire.
Dracula turns his attention to Mina and begins corrupting her as well. Van Helsing suddenly has a stroke and remains in a wheelchair. Dracula visits the weakened man, mocking his attempts to destroy him. Quincey, Harker and Seward track Dracula to the abandoned abbey, but he has fled to Transylvania with the aid of a traveling Gypsy band.
Meanwhile, at the clinic, Renfield suffers a shock and dies peacefully.
As Count Dracula’s Gypsy servants take him back to his castle, he is trailed by Harker and Quincey. After battling the Gypsies, the two heroes find Dracula’s coffin and set it on fire. Dracula, unable to escape in full daylight, is consumed by flames.