Margaret White, a disturbed religious fanatic, sits alone in her home on her bed and gives birth to a baby girl. She intends to kill the infant but changes her mind.
Years later, her daughter Carrie, a shy, unassertive girl, nears her graduation from Ewen High School in Maine. While showering after the gym at school, Carrie experiences her first menstrual period. Never having been taught to prepare for this, she believes she is bleeding to death and runs out of the shower yelling for help. The other girls ridicule her by throwing tampons and pads at her. Longtime bully Christine “Chris” Hargensen records everything on her smartphone and uploads it to YouTube. Miss Rita Desjardin, the gym teacher, comforts Carrie and sends her home with Margaret, who believes menstruation is a sin. Margaret demands that Carrie abstain from showering with the others. When Carrie refuses, Margaret hits her in the forehead with a Bible and locks her in her “prayer closet.” As Carrie screams to be let out, a crack appears on the door, and the crucifix in the closet begins to bleed. Carrie begins to experience more signs over the oncoming days that point to her having telekinesis. She researches her abilities, learning to harness them.
Miss Desjardin informs the girls who teased Carrie that they are given a choice to either endure boot-camp-style detention for their behavior or be suspended from school, prohibiting them from attending prom; Chris is the only one who refuses to take part in detention and is suspended from school after denying the allegation and refusing to give up her smartphone. Sue Snell regrets her part in the incident. To make amends, she asks her boyfriend, Tommy Ross, to take Carrie to the prom. Carrie accepts Tommy’s invitation and makes a prom dress at home. Her mother, Margaret, forbids Carrie to attend. Asking her mother to relent, Carrie manifests her telekinesis. Margaret believes this power comes from the Devil and is proof that Carrie has been corrupted by sin. Meanwhile, Chris, her boyfriend Billy Nolan, and his friends plan revenge on Carrie; they obtain pig blood to put in a bucket.
On Prom Night, Margaret tries to prevent Carrie from going, but Carrie uses her powers to lock her mother in the closet. At the prom, Carrie is nervous and shy, but Tommy kindly puts her at ease. As part of Chris and Billy’s plan, Chris’ friend, Tina Blake, discreetly slips fake ballots into the voting box, which names Carrie and Tommy as prom queen and king. At home, Sue receives a text from Chris, taunting her about her scheme to humiliate Carrie. Sue drives to the prom, arriving just as Carrie and Tommy are about to be crowned. Billy warns Chris not to tell anyone about the bucket as it is criminal assault; Chris agrees to say nothing. Sue sees the bucket of blood dangling above Carrie and attempts to warn someone. Desjardin locks her out of the gym, suspecting that Sue plans to hurt Carrie.
Chris dumps the blood onto Carrie and Tommy. Nicki plays the “shower video” of Carrie on the large screens above the stage, inciting laughter from some in the audience. Carrie pushes Miss Desjardin with her powers when Desjardin attempts to help her. The bucket falls onto Tommy’s head, killing him. Enraged, Carrie takes her revenge and uses her telekinesis to kill nearly every student and staff, but spares Desjardin. An electrical wire merges with leaking water, and a fire breaks out. As the school burns to the ground, Carrie walks away, leaving behind a trail of destruction. Chris and Billy attempt to drive away, but Carrie crashes the car, killing Billy. Chris attempts to run Carrie over, but Carrie lifts the car and throws it at a gas station, killing her. Carrie tips over an electric power pole, setting the car on fire.
Carrie arrives home and takes a bath and changes into her nightgown afterward. Carrie tearfully tells Margaret about the prank. Carrie and Margaret embrace and Margaret recounts Carrie’s conception. After having shared a bed platonically with her husband, they yielded to temptation one night, and, after praying for strength, Carrie’s father “took” Margaret, who enjoyed the experience. After the talk, Margaret stabs Carrie in the back with a knife. She declares that she must kill Carrie in order to prevent the Devil from possessing her again and attacks Carrie, but Carrie kills her with several sharp tools. She becomes hysterical and makes stones rain from the sky to crush the house. When Sue arrives, a furious Carrie lifts her with her powers but senses that Sue is pregnant with a baby girl. Carrie protects Sue and throws her out of the house to safety as the house collapses and sinks, apparently killing Carrie as well.
After giving her testimony in court regarding the prom incident, Sue visits Carrie and Margaret’s grave, which has been vandalized to read “CARRIE WHITE BURNS IN HELL,” and places white roses by the headstone. As she leaves, the gravestone begins to break, and Carrie’s enraged scream is heard.