A new wing at Britannia Hospital is to be opened, and the Queen Mother—referred to as HRH—is due to arrive. The administrator of the hospital, Potter (Leonard Rossiter), is confronted with demonstrators protesting against an African dictator who is a VIP patient, striking ancillary workers (opposed to the exotic gastronomic demands of the hospital’s private patients) and a less-than-cooperative Professor Millar (Graham Crowden), the head of the new wing. Rather than cancel the royal visit, Potter decides to go out and reason with the protestors. He strikes a deal with the protest leader—the private patients of Britannia Hospital are to be ejected and, in return, the protestors allow a number of ambulances into the hospital. However, unbeknown to the protestors, these ambulances actually contain the Queen Mother and her entourage.
Mick Travis (Malcolm McDowell) is a reporter who is shooting a clandestine documentary about the hospital and its dubious practices. He manages to get inside and starts to investigate Millar’s sinister scientific experimentation, including the murder of a patient, Macready (Alan Bates). As mayhem ensues outside, Travis is also murdered and his head used as part of a grim Frankenstein-like experiment which goes hideously wrong.
Eventually, the protestors break into the hospital and attempt to disrupt Millar’s presentation of his Genesis Project, in which he claims he has perfected mankind. In front of the assembled audience of Royalty and commoners, Genesis is revealed—a brain wired to machinery. Genesis is given a chance to speak and, in a robotic voice, utters the “What a piece of work is a man” speech from Hamlet, until it continuously repeats the line “How like a God”.